INTEGRA® Dermal Regeneration
Template is indicated for the post-excisional
treatment of life threatening full-thickness
or deep partial-thickness thermal injuries
where sufficient autograft is not available
at the time of excision or not desirable due
to the physiological condition of the patient.
INTEGRA® Dermal Regeneration
Template is also indicated for the repair
of scar contractures when other therapies
have failed, or when donor sites for repair
are not sufficient or desirable due to the
physiological condition of the patient.
INTEGRA® Dermal Regeneration
Template is a bi-layer skin replacement system
composed of a dermal regeneration layer and
a temporary epidermal layer. Within the dermal
regeneration layer the collagen-glycosaminoglycan
(GAG) matrix provides an environment for cellular
infiltration, native collagen deposition,
and neovascularization. This biodegradeable
template induces the organized regeneration
of dermal tissue by the body. The result,
"Neodermis", is functionally normal
dermis produced without skin appendages.
The Stern study demonstrated
an intact dermis was achieved with regrowth
of apparently normal reticular and papillary
dermis. In addition, no scar formation appeared
at any time during the course of healing in
any of the biopsies of the patients examined.
In the first surgical procedure
the wound is excised to viable tissue and
INTEGRA Template is applied. Over the next
2-3 weeks, the dermal layer is regenerated
while simultaneously degrading the collagen-GAG
matrix. The biodegradable template induces
organized regeneration of normal dermal tissue
("Neodermis") by the body. At approximately
21 days, in a second surgical procedure following
dermal regeneration, the silicone layer is
removed and a thin epidermal autograft 0.004-0.006 inches (0.1016 - 0.1524 millimeters) is applied. The thin donor site will
heal faster and can be harvested more frequently
than conventional donor sites which are typically
2-3 times deeper. Engraftment and confluence
of the epidermal graft complete the process
in about 30 days from the first procedure.
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Introduction to INTEGRA® Dermal Regeneration
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