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How INTEGRA Works
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When INTEGRA Template is placed on a wound where burned or scarred skin has been removed, INTEGRA provides the needed framework for the blood vessels and dermal skin cells to re-grow into a new skin layer. The silicone outer layer temporarily closes the wound to ward off infection and control fluid and heat loss.

As skin cells migrate into the matrix the collagen is slowly absorbed into the body and replaced with protein that is naturally produced by the skin. In approximately 14 to 21 days, new dermal skin is produced and the silicone layer can be removed. A thin skin graft of the person's epidermis is applied to the wound area to complete the procedure.

In total, the two surgical procedures are typically completed within 30 days. A person is left with flexible growing skin and minimal damage at the skin graft donor sites.



This video illustrates the process of dermal regeneration from
reconstructive surgery.


Clinical Sequence

DAY 0:
PRE-TREATMENT

The burn injury or scar contracture is assessed and evaluated

DAY 0: PRE-TREATMENT

DAY 1:
EXCISION

The wound is cleaned and the damaged tissue or contracture scar is completely excised (removed) down to viable tissue in preparation for the application of the INTEGRA Template

DAY 1: EXCISION

DAY 1:
APPLICATION

INTEGRA Template is applied to the excised wound bed. Fluids invade the matrix within minutes of application,
adhering it to the wound.

DAY 1: APPLICATION

DAY 7-14:
NEW DERMIS FORMATION

Dermal cells begin migrating into the matrix and establish a new vascular network. As healing progresses, the
collagen (protein) in the INTEGRA Template is replaced by collagen organically produced by new dermal
skin cells.

DAY 7-14: NEW DERMIS FORMATION

DAY 21+:
SILICONE REMOVAL

Upon formation of a new dermal layer, the INTEGRA silicone layer is removed. The INTEGRA collagen template biodegrades and is absorbed into the body, leaving new dermal skin.

DAY 21+: SILICONE REMOVAL

DAY 21+:
EPIDERMAL AUTOGRAFT

A thin 0.004 – 0.006 in. (0.1016 - 0.1524 mm) epidermal autograft is applied over the new dermal skin

DAY 21+: EPIDERMAL AUTOGRAFT

DAY 25-56:
REGENERATED SKIN

Successful engraftment completes the procedure yielding a permanent and lasting wound closure

DAY 25-56: REGENERATED SKIN

 

 
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