| INTEGRA™
Matrix Wound Dressing is placed on a surgically
debrided or excised wound, it provides the needed
framework for the blood vessels and dermal skin cells
to remodel the damaged site.
As skin cells migrate into the
matrix, the collagen is slowly absorbed and replaced
with collagen produced from the person's own cells.
In approximately 14 to 21 days, the scaffold is
eventually remodeled as the patient's cells rebuild
the damaged site. Complete wound closure occurs
as epidermal cells migrate from the wound edges.
For larger wounds, a thin skin
graft of the person's epidermis may be applied to
the wound area to facilitate complete wound closure.
Wound closure is typically
complete within 30 days. A person is left with a
healed wound created from their own tissue.
Clinical Sequence
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DAY 0:
PRE-TREATMENT
Patients must have accurate
diagnosis and treatment of underlying disease
and risks. There must be thorough pre-operative
control of inflammation, ulceration, debris
and bioburden, and edema (as best as the disease
and available treatments permit).
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DAY 1:
DEBRIDEMENT
Prepare wound bed using
standard methods to ensure wound is free of
debris and necrotic tissue. Regardless of
how well the wound has been prepared and how
healthy it looks, INTEGRA™
Matrix Wound Dressing must not be placed
on an existing wound surface. The entire existing
wound must be completely excised or surgically
debrided to ensure the wound bed and edges
contain viable tissue.
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DAY 1:
APPLICATION
INTEGRA™
Matrix Wound Dressing is applied to
the excised wound bed (A).
Fluids invade the matrix within minutes of
application, adhering it to the wound. The
INTEGRA must conform to and contact the wound
surface. It can be affixed with sutures, staples,
or any suitable alternative.
For deeper wounds INTEGRA™
Matrix Wound Dressing (B) can be used
in combination (C)
with INTEGRA™
Bilayer Matrix Wound Dressing.
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DAY 7-14:
CELLULAR INVASION and CAPILLARY GROWTH
Cells begin migrating into
the matrix and establish a new vascular network.
The scaffold is eventually remodeled as the
patient's cells rebuild the damaged site.
When using either the Matrix
or Bilayer Matrix dressings, the collagen
template biodegrades and is absorbed into
the body.
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DAY 21-56+:
WOUND CLOSURE
Epidermal cells migrate
from the wound edges to complete wound closure.
For larger wounds, a thin epidermal autograft
may be considered to facilitate wound closure.
A thin 0.004 – 0.006 in. (0.1016 - 0.1524
mm) epidermal autograft may be applied over
the new remodeled skin.
Epidermal coverage over the wound yields a permanant
and lasting wound closure. |
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