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How INTEGRA™ Bilayer Matrix Wound
Dressing Works
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INTEGRA™ Bilayer Matrix Wound Dressing is placed on a surgically debrided or excised wound, it provides the needed framework for the blood vessels and dermal skin cells to remodel the damaged site.

As skin cells migrate into the matrix, the collagen is slowly absorbed and replaced with collagen produced from the person's own cells. In approximately 14 to 21 days, the scaffold is eventually remodeled as the patient's cells rebuild the damaged site and the silicone layer removed. Complete wound closure occurs as epidermal cells migrate from the wound edges. For larger wounds, a thin skin graft of the person's epidermis may be applied to the wound area to facilitate complete wound closure.

Wound closure is typically complete within 30 days. A person is left with a healed wound created from their own tissue.



Clinical Sequence

DAY 0:
PRE-TREATMENT

All chronic wound patients must have accurate diagnosis and treatment of underlying disease and risks. There must be thorough pre-operative control of inflammation, ulceration, debris and bioburden, and edema (as best as the disease and available treatments permit).

DAY 0: PRE-TREATMENT

DAY 1:
DEBRIDEMENT

Prepare wound bed using standard methods to ensure wound is free of debris and necrotic tissue. Regardless of how well the wound has been prepared and how healthy it looks; INTEGRA™ Bilayer Matrix Wound Dressing must not be placed on an existing wound surface. The entire existing wound must be completely excised or surgically debrided to ensure the wound bed and edges contain viable tissue.

DAY 1: EXCISION

DAY 1:
APPLICATION

INTEGRA™ Bilayer Matrix Wound Dressing is applied to the excised wound bed. Fluids invade the matrix within minutes of application, adhering it to the wound. The Integra must conform to and contact the wound surface. Tension within the material will shear the matrix from the silicone, so the material must not be stretched. It can be affixed with sutures, staples, or any suitable alternative.

DAY 1: APPLICATION

DAY 7-14:
CELLULAR INVASION and CAPILLARY GROWTH

Dermal cells begin migrating into the matrix and establish a new vascular network. The scaffold is eventually remodeled as the patient's cells rebuild the damaged site.

DAY 7-14: NEW DERMIS FORMATION

DAY 21+:
SILICONE REMOVAL

The silicone layer is removed. The collagen template biodegrades and is absorbed into the body.

DAY 21+: SILICONE REMOVAL

DAY 21-56+:
WOUND CLOSURE

Epidermal cells migrate from the wound edges to complete wound closure. For larger wounds, a thin epidermal autograft may be considered to facilitate wound closure. A thin 0.004 – 0.006 in. (0.1016 - 0.1524 mm) epidermal autograft may be applied over
the new remodeled skin
.

Epidermal coverage over the wound yields a permanant and lasting wound closure.
DAY 21+: EPIDERMAL AUTOGRAFT
DAY 25-56: REGENERATED SKIN

 

 
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